Undifferentiated pleomorphic sarcoma is a common soft tissue sarcoma in the human body, but it is rarely reported in the oral cavity. This article aims to report a case of UPS in the mandible. An 83-year-old female patient was referred to the Department of Oral and Maxillofacial Pathology at the Faculty of Dentistry in Isfahan, Iran, with a complaint of sudden, painless swelling under her removable complete denture, which had grown gradually over three months. The size of the lesion was approximately 5cm, and there were no radiographic defects present. Neoplastic and malignant proliferation of cells, which is necessary for UPS final diagnosis, was present in the H&E microcopy evaluation. Furthermore, immunohistochemical examination proved that the lesion is an undifferentiated pleomorphic sarcoma. Because of the late diagnosis of the disease, the patient died due to lung metastasis before any treatment.  Keywords: Case report; Surgery; Undifferentiated pleomorphic sarcoma; Malignant fibrous histiocytoma.

Malignant Fibrous Histiocytoma (MFH) is the most common soft-tissue sarcomawhich predominantly surfaces in the retro-peritoneum and extremity. MFH of lungis a very rare condition. The diagnosis is essentially through histologicexamination. However, the invasion of the chest wall or other organs might helpestablish the malignant nature.We report a case of a 77-year-old man who hadbeen presented with a history of dyspnea and non-massive hemoptysis. ComputedTomography (CT) scan of the chest showed a lobulated mass which had developedinto the hilum of the lung. Furthermore, the inferior pulmonary artery wasinvaded. Thus, the final histological diagnosis confirmed MFH. The patientunderwent a left pneumonectomy along with the dissection of the regional lymphnodes. Although lung MFH is rather an uncommon condition, it must be taken intoconsideration in differentiating between the types of lung tumor. What can beconcluded is that complete surgical resection is the essential approach.

Introduction: Oral metastases are rare,nevertheless, they must be considered in the differential diagnosis of lesions in patients with a previous history of malignancy or older adults. The clinical signs of oral metastasis typically comprise pain, dysphagia, ulceration, bleeding, and paresthesia. Soft tissue sarcomas tend to affect the extremities and retroperitoneum. The most common metastases in the oral cavity are carcinomas, and sarcomas rarely metastasize to this area. Undifferentiated pleomorphic sarcoma (UPS) is a mesenchymal malignancy that infrequently affects the head and neck site. It shows a male predilection and occurs in all age groups. The lung is the most common area of distant metastasis in undifferentiated pleomorphic sarcoma. Case Report: This report presents a 61-year-old female patient with a painful bluish-purple mass of the posterior right mandibular alveolar mucosa. She had a history of thigh UPS about four years ago. An incisional biopsy was performed, and the specimen was stained with hematoxylin and eosin. Immunohistochemical antibodies for CK, S100, desmin, myogenin, MDM2, SOX10, and caldesmon were negative and focally positive for CD68. Ki-67 index was about 70%. Conclusions: This report aimed to increase awareness of a rare lesion by describing the clinical, histopathologic, and immunohistochemical findings of metastatic undifferentiated pleomorphic sarcoma of the oral cavity.

Malignant fibrous histiocytoma is the most common soft tissue sarcoma in adults. The common sites of involvement are the retroperitoneal space and limbs. The occurrence of this tumor in the head and neck is rare. Recent studies have shown that the occurrence of malignant fibrous histiocytoma in the head and neck can follow radiotherapy for the treatment of other tumors. We, herein, report a case of malignant fibrous histiocytoma, which developed 17 years after radiotherapy of a carcinoma in the maxillary sinus.

Malignant fibrous histiocytoma (MFH) is one of the most common types of soft tissue sarcomas in adults. Distant metastases are developed in 30– 40% of patients with MFH, with the most common site being the lung. However, metachronous MFH has not been reported previously in literature. This report describes a case of a 30-yearold man, who had two metachronous thigh tumors, both of which were confirmed to be MFH on histopathology and immunohistochemistry evaluations. A contemporary multidisciplinary approach to therapy including surgery, radiation and chemotherapy was advocated. Two primary sites of MFH raised the possibility of a genetic abnormality that could predispose such a patient to develop multiple primary sites of the same tumor.

Introduction: Sarcomas account for 1% of all tumors originated in the head and neck regions in adults. They constitute a heterogeneous group of tumors of mesenchymal origin with multiple histological variants. The undifferentiated pleomorphic sarcoma (UPS) subtype is the most frequent variant with an incidence range of 2. 7-38%. Materials and Methods: This retrospective case series was conducted on 11 patients who were diagnosed with UPS and treated in our institution in the last 11 years. Results: According to the results, 26. 8% of the sarcomas corresponded to UPS variant. Out of 11 patients, 5 cases were female. The median age of the participants was 58 years (range: 18-74 years). Seven and four patients were T1b and T2b, respectively. Ten patients had no metastasis at the moment of diagnosis. Six patients were categorized as intermediate-grade, and the remaining (n=5) were classified as high-grade. The most frequent location was the scalp (n=3). In the patients undergoing surgery, the mean follow-up duration was 52 months. Disease-free survival (DFS) rates were obtained at 70%, 50%, and 50% in the 1st, 3rd, and 5th years, respectively, with the mean DFS of 36 months. In addition, the overall survival rates in the 1st, 3rd, and 5th years were 100%, 100%, and 83%, respectively. Conclusion: The UPS represented the most common histological subtype in our series. They tend to be intermediate or high-grade tumors. An acceptable global survival rate justifies surgical treatment as the main therapeutic tool.